Dr. Steve Goldup

Steve obtained an MChem degree from the University of Oxford where he began his research career with a Part II project in the group of Sir Prof. Jack Baldwin. He continued his research training with a PhD in natural product synthesis under the supervision of Prof. Tony Barrett before shifting focus to apply his synthetic skills to the realisation of mechanically interlocked non-natural products during post doctoral work with Prof. David Leigh at the University of Edinburgh where in 2007 he was appointed as Fixed Term Lecturer in Organic Chemistry. In 2008 he moved to Queen Mary with the award of a Leverhulme Trust Early Career Fellowship and in October 2009 he was awarded a Royal Society University Research Fellowship. In October 2014 the group moved to the University of Southampton where Steve took up the position of Associate Professor. Research in the Goldup Group focusses on the synthesis of novel mechanically interlocked molecules and their application as sensors, catalysts and materials.



Small Functional Rotaxanes
Stephen Goldup

Chemistry, University of Southampton
Southampton, Hampshire, SO17 1BJ, United Kingdom
The active template approach to mechanically interlocked molecules is a versatile and powerful method for synthesising catenanes and rotaxanes which are difficult or impossible to form using other methods.[1] Our group have pioneered the use of “small” macrocycles[2] in active template reactions in order to allow the synthesis of small(er), functionalised rotaxanes in excellent yield.[3] I will describe some of our recent applications of this methodology to the synthesis of functional interlocked molecules including sensors and catalysts[4] and discuss our pioneering work on mechanically chiral rotaxanes (Fig. 1), a previously hard to access class of chiral molecules.[5]

Fig 1. Cartoon Representation of Mechanically Chiral Rotaxanes

[1] J. D. Crowley, S. M. Goldup, A.-L. Lee, D. A. Leigh, R. T. McBurney, Chem. Soc. Rev. 2009, 38, 1530.
[2] J. E. M. Lewis, R. J. Bordoli, M. Denis, C. J. Fletcher, M. Galli, E. A. Neal, E. M. Rochette, S. M. Goldup, Chem. Sci. 2016, 7, 3154.
[3] H. Lahlali, K. Jobe, M. Watkinson, S. M. Goldup, Angew. Chem., Int. Ed. 2011, 50, 4151.
[4] M. Galli, J. E. M. Lewis, S. M. Goldup, Angew. Chem. Int. Ed. 2015, 54, 13545.
[5] R. J. Bordoli, S. M. Goldup, J. Am. Chem. Soc. 2014, 136, 4817.